Project Background


Project Summary

Emerging antibiotic resistance has become an endemic problem, slowly increasing under the radar and depriving future generations of effective therapies.

The goal of the EU-funded project REVERSE (pREVention and management tools for rEducing antibiotic Resistance in high prevalence SEttings) is to develop and implement cost-effective strategies and tools for the prevention and clinical management of healthcare-associated infections due to multidrug-resistant pathogens, and to reduce the burden of antimicrobial resistance in high-prevalence healthcare settings.

To achieve these goals, REVERSE will use a mixed-methods approach combining quantitative research with implementation science and economic analysis.

The aim is to produce results that go beyond the evidence base we have today.

REVERSE will answer questions about real-life effectiveness of infection prevention and control programmes in combination with antibiotic stewardship on healthcare-associated infections due to multidrug-resistant microorganisms. It will offer implementation strategies to the participating hospitals, as well as studying the effectiveness of external implementation support in a hybrid implementation-effectiveness trial.

REVERSE will develop a novel health-economic framework that allows for the incorporation of changes in the use of a range of antibiotics on antibiotic resistant infections. It will also estimate long-term population effects and integrate both into cost-effectiveness analyses. Conclusions on effectiveness and applicability of prevention strategies in lower-resource settings by cross-checking its programmes with activities in low-and-middle income countries will be drawn. 

At the completion of the project, four European countries (Greece, Italy, Romania and Spain) will have a platform of highly experienced hospitals to build on, and expand a national network for combatting antibiotic resistance. 



Project Objectives

Objective 1

Design and evaluation of an integrated, modular strategy of evidence-based intervention programmes that can be implemented in the clinical management of hospitalized patients in high antimicrobial resistance prevalence settings.

Objective 2

Design and evaluation of a tailored enhanced implementation strategy versus a standard basic implementation strategy to introduce evidence-based interventions in high antimicrobial resistance prevalence settings.

Objective 3

Estimation of the cost-effectiveness of the intervention programmes for the prevention and clinical management of infections and colonisation due to antimicrobial-resistant pathogens.

Objective 4

Development of recommendations and implementation strategies on antimicrobial resistance prevention and clinical management strategies in high antimicrobial resistance prevalence settings in Europe, and exploration of the transferability of the proposed intervention programmes to low-and-middle-income countries outside Europe.

Objective 5

Obtaining a change of the local organisational way of working in the participating hospitals and to engage them as European reference hospitals for sustainability and further dissemination.



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