Work Package 5: Implementation

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Work package 5 has the following objectives:

1. Understand contextual barriers and facilitators for the implementation of antibiotic stewardship, microbiology and diagnostic stewardship and infection prevention and control measures in acute care hospitals in regions with high antimicrobial resistance prevalence.

2. Develop generalisable knowledge about the determinants influencing implementation of infection prevention and control, antibiotic stewardship and microbiology and diagnostic stewardship practices in a diverse group of European hospitals.

3. Design and evaluate a tailored implementation strategy as compared with a standard implementation strategy as part of a type 2 hybrid implementation-effectiveness trial.

4. Produce tools for implementing antibiotic stewardship and infection prevention and control, taking into account organisational culture, national strategies, and the hospital networks along their referral pathways.

5. Engage regional and national stakeholders in healthcare and politics to engage in antibiotic stewardship and infection prevention and control.

 

Leading Partner

University of Zurich

 

Other Partners Involved

University of Geneva

Publications
Publications
Relevant Publications

  • Caci, L., Blum, K., Clack, L., & Albers, B. (2026). Factor selection in configurational comparative analysis – guidance for implementation researchers. Implementation Science Communications, 7(1), Article 95. https://doi.org/10.1186/s43058-026-00981-4

    Publication date: 19 June 2026

    Authors: Caci, L., Blum, K., Clack, L., Albers, B.

    Journal: Implementation Science Communications

    Title: Factor selection in configurational comparative analysis – guidance for implementation researchers

    Abstract:

    Link(s): Read the Paper

    File(s): PDF of the paper

  • Caci, L., Blum, K., Johnson, C. et al. Organizational readiness for implementing infection control in European hospitals: insights from Coincidence Analysis. Implement Sci Commun(2026). https://doi.org/10.1186/s43058-026-00884-4

    Publication date: 25 February 2026

    Authors: Caci, L, Blum, K, Johnson, C, Albers, A, Clack, L

    Journal: Implementation Science Communications

    Title: Organizational Readiness for Implementing Infection Control in European Hospitals: Insights from Coincindence Analysis.

    Abstract:

    Link(s): Read the Paper

    File(s): PDF of Paper

  • Blum, K., Braathu, N., Caci, L., Nyantakyi, E., Prang, K.-H., Schultes, M.-T., Wu, C. X., Albers, B., & Clack, L. (2026, February 12). Developing a framework for ongoing tailoring and its monitoring in health care: Insights from a systematic review [Poster presentation]. 4th Impact Conference, Zurich, Switzerland.

    Publication date: 12 February 2026

    Authors: Blum, K, Braathu, N, Caci, L, Nyantakyi, E, Prang, K.-H, Schultes, M.-T, Wu, C. X, Albers, B, Clack, L

    Journal:

    Title: Developing a Framework for Ongoing Tailoring and its Monitoring in Healthcare: Insights from a Systamatic Review

    Abstract:

    Link(s): -

    File(s): 2026_02_10_Poster_BlumK_4thIMPACTconference.jpg

  • Albers, B., Caci, L., Blum, K. et al. Examining tailoring as an implementation strategy for reducing healthcare-associated infections across European acute care hospitals (REVERSE): study protocol for a hybrid type 2 effectiveness-implementation trial. Trials 26, 418 (2025).

    Publication date: 23 October 2025

    Authors: Albers, B., Caci, L., Blum, K., Boland, G., Carrara, E., Retamar Gentil, P., Nguyen, A., Pollard, J., Schechner, V., Sonpar, A., Yanagida, T., Zingg, W., and Clack, L.

    Journal: Trials

    Title: Examining tailoring as an implementation strategy for reducing healthcare-associated infections across European acute care hospitals (REVERSE): study protocol for a hybrid type 2 effectiveness-implementation trial.

    Abstract:

    Link(s): https://trialsjournal.biomedcentral.com/articles/10.1186/s13063-025-09132-x

    File(s): Protocol_Trials.pdf

  • Caci, L., Nyantakyi, E., Blum, K., Sonpar, A., Schultes, M.-T., Albers, B., & Clack, L. (2025). Organizational readiness for change: A systematic review of the healthcare literature. Implementation Research and Practice, 6. https://doi.org/10.1177/26334895251334536 (Original work published 2025)

    Publication date: 15 May 2025

    Authors: Caci, L, Nyantakyi, E, Blum, K., Sonpar, A., Schultes, M.-T., Albers, B., Clack, L.

    Journal: Implementation Research and Practise

    Title: Organizational Readiness for Change: A Systematic Review of Healthcare Literature

    Abstract:

    Link(s): Read More

    File(s): -

  • Albers, B., Verweij, L., Blum, K., Oesch, S., Schultes, M.-T., Clack, L., & Naef, R. (2024). Firm, yet flexible: a fidelity debate paper with two case examples. Implementation Science, 19(1), 79. https://doi.org/10.1186/s13012-024-01406-3 

    Publication date: 12 December 2024

    Authors: Albers, B., Verweij, L., Blum, K., Oesch, S., Schultes, M.-T., Clack, L., Naef, R.

    Journal: Implementation Science

    Title: Firm, yet Flexible: a Fidelity Debate Paper with Two Case Examples

    Abstract:

    Link(s): Read

    File(s): -

  • Blum, KA, Braathu, N, et al. (for the REVERSE study group). Ongoing tailoring could guide implementation in practice and be evaluated in research if concepts, core elements, and methods were clearly defined. Poster presented at: The Swiss Implementation Science Network Conference (IMPACT); 7-8 November 2024; Geneva, Switzerland. 

    Publication date: 07 November 2024

    Authors: Kathrin A. Blum, Nora Braathu, Laura Caci, Emanuela Nyantakyi, Khic-Houy Prang, Marie-Therese Schultes, Bianca Albers, Lauren Clack.

    Journal: Poster presented at The Swiss Implementation Science Network Conference (IMPACT) 2024.

    Title: Ongoing tailoring could guide implementation in practice and be evaluated in research if concepts, core elements, and methods were clearly defined.

    Abstract:

    Link(s): -

    File(s): K_BlumIMPACT.pdf

  • Blum, KA, Braathu N, et al. (for the REVERSE Study Group) Ongoing tailoring (OT) could guide implementation in practice and be evaluated in research if concepts, core elements, and methods were clearly defined. Poster presented at: Society for Implementation Research Conference (SIRC); 11 October 2024; Denver, United States. 

    Publication date: 11 October 2024

    Authors: Kathrin A. Blum, Nora Braathu, Laura Caci, Emanuela Nyantakyi, Khic-Houy Prang, Marie-Therese Schultes, Bianca Albers, Lauren Clack.

    Journal: Poster presented at the Society for Implementation Research Conference 2024.

    Title: Ongoing tailoring (OT) could guide implementation in practice and be evaluated in research if concepts, core elements, and methods were clearly defined.

    Abstract:

    Link(s): -

    File(s): 2024_10_11_SIRC_BlumK.pdf

  • Caci, L, Albers, B, et al. (for the REVERSE Study Group) Configurational Comparative Analysis in REVERSE. Poster presented at: The Swiss Implementation Science Network Conference; 7 - 8 November 2024; Geneva, Switzerland. 

    Publication date:

    Authors: Laura Caci, Bianca Albers, Kathrin Blum, and Lauren Clack.

    Journal: Poster presented at The Swiss Implementation Science Network Conference (IMPACT) 2024.

    Title: Configurational Comparative Analysis in REVERSE

    Abstract:

    Link(s): -

    File(s): v2_IMPACT2024_REVERSE CNA_LC.pdf

 

 

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